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pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly increase the metabolism of ifosfamide to its active alkylating metabolites.pentobarbital will reduce the level or result of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metab